Arsenal manager Mikel Arteta is forced to make five changes as he rotates his team after their defeat against Manchester City three days ago, with Holding, Pepe, Ceballos, Lacazette and Kolasinac all coming into the side. On-loan defender Pablo Mari and midfielder Granit Xhaka both miss out after suffering injuries early on in that game, while Nketiah, Willock and Tierney drop to the bench. David Luiz is suspended after being sent off against the reigning champions, while Calum Chambers, Lucas Torreira, Cedric Soares and Sokratis Papastathopoulos are all unavailable due to injury.
Arsenal substitutes: Emiliano Martinez, Mesut Ozil, Reiss Nelson, Zech Medley, Eddie Nketiah, Joe Willock, Gabriel Martinelli, Ainsley Maitland-Niles, Kieran Tierney.
Arsenal XI (4-3-3): Bernd Leno; Hector Bellerin, Shkodran Mustafi, Rob Holding, Sead Kolasinac; Matteo Guendouzi, Dani Ceballos, Bukayo Saka; Nicolas Pepe, Alexandre Lacazette, Pierre-Emerick Aubameyang.
Brighton and Hove Albion substitutes: Tariq Lamptey, Glenn Murray, Solly March, Alexis Mac Allister, Aaron Connolly, Shane Duffy, Martin Montoya, David Button, Dale Stephens.
Brighton and Hove Albion XI (4-2-3-1): Mat Ryan; Ezequiel Schelotto, Adam Webster, Lewis Dunk, Dan Burn; Davy Propper, Yves Bissouma; Aaron Mooy, Pascal Gross, Leandro Trossard; Neal Maupay.
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